Research Into Ailments and the use of CBD

For Your Information

People often ask if Pure Presence CBD will be able to help them with whatever ails them ,  unfortunately I do not have the answer to that and can offer no guarantees especially with the interaction of their prescribed drugs. What I can do is research as much as I can and share with you my findings and hope this in some way can help.

Can Cannabis Help With Atrial Fibrillation?

Atrial fibrillation — or AFib in short — is a condition characterized by irregular heartbeats also known as arrhythmia. When untreated, it can result in heart failure, stroke, blood clotting, and other cardiovascular problems.

It’s estimated that around 2.7 million Americans are living with AFib. Doctors typically prescribe blood thinners such as warfarin to help prevent strokes in patients with this condition.

There’s a growing body of evidence surrounding the benefits of CBD for the cardiovascular system.

Short for cannabidiol, CBD is one of many substances found in cannabis. It’s the second major cannabinoid next to THC, which is the main intoxicating ingredient in marijuana (high-THC cannabis).

Unlike THC, CBD doesn’t get you high, but instead, it helps you enjoy the plethora of health benefits associated with this compound.

In this article, we’ll leave no stone unturned exploring the use of CBD for AFib.

Does CBD Oil Help AFib?

A 2010 study posted by the British Journal of Pharmacology discovered that CBD reduced the total number of irregular, ventricular heartbeats (heart arrhythmia) in a rat model after they had a heart attack. This type of arrhythmia that doesn’t come from the atria but rather from the ventricles is different from AFib, but the said findings could be worth further analysis.

In a 2017 study, the research team learned that a single dose of CBD reduced blood pressure in male subjects. They also noted that CBD lowered blood pressure response to stress in the subject, particularly in the event of cold stress.

Elevated blood pressure is believed to increase the risk of atrial fibrillation in middle-aged men and women.

Another study investigated the theory that CBD can attenuate responses and consequences of stress in animals with anxiety.

In the meantime, experts in another study concluded that CBD inhibited several processes linked to diabetes, pointing to CBD as a potentially therapeutic substance in treating diabetes and other heart-related diseases.

That being said, there are no studies that would investigate CBD’s efficacy as a treatment for atrial fibrillation. Many studies on CBD were conducted on animal models, with only a few small studies on human subjects —butt none directly tackle the problem of AFib.

How does CBD Oil work for AFib?

CBD interacts with the major regulatory network in our bodies known as the endocannabinoid system (ECS). ECS works to promote and maintain homeostasis in the body through its receptors; for that purpose, it releases ligands known as endocannabinoids.

CBD has been found to indirectly engage with cannabinoid receptors type 1 and 2 (CB1 and CB2), but there’s also a growing body of evidence that it works on multiple pathways beyond the ECS.

One study on lab rats found that CBD’s interaction with the ECS causes it to exert cardioprotective effects in the animals. In another study, the authors reported that CBD binds to and activates the PPARgamma receptor, which has been associated with various cardiovascular illnesses.

They also noted that the activation of the said receptor-induced vascular actions in rats.

Good blood pressure control is beneficial for AFib patients. There are already safe, established medications for this condition, but CBD can add yet another choice for patients that want to treat their AFib with holistic remedies.

Potential Benefits of CBD Oil for AFib

• Some studies highlight CBD’s ability to control blood pressure, which could translate into better AFib control. The studies we’ve mentioned above noted that CBD offers benefits for the cardiovascular system and can help treat another type of arrhythmia but — not AFib specifically.

• There is evidence that CBD can reduce hypertension, a condition that causes atrial fibrillation.

• CBD doesn’t have intoxicating properties, so it won’t get you high, unlike THC

• Public health agencies such as NIH and the FDA acknowledge CBD’s potential therapeutic uses.

• The WHO issued a case report where they reviewed several clinical trials investigating the efficacy and safety of CBD. The report concluded that CBD is safe and well-tolerated, even when taken in large amounts.

What Are the Limitations of Using CBD Oil for AFib?

• Most of the studies on CBD were conducted on animal models. There are currently no clinical human trials on the use of CBD for AFib. The effects have not been directly studied with regards to this condition.

• The only FDA-approved use of CBD is for epilepsy — and it’s not even CBD oil but synthetically isolated CBD.

• Taking CBD oil alongside other medications, especially blood thinners, can lead to negative interactions. In the case of CBD and blood-thinners, the cross-interaction could trigger bleeding, so always talk to your doctor before taking CBD.

• The CBD market is unregulated and thus there are many mislabelled products sold online. People choosing to buy CBD for AFib should be particularly cautious of who they’re buying from.

• Please check out our certificates of authentication

https://cfah.org/cbd-oil-for-afib/ 

Julia, N. (2022) CBD Oil and AFIB: Can cannabis help with atrial fibrillation?, CFAH. Available at: https://cfah.org/cbd-oil-for-afib/ (Accessed: 23 July 2023).

Fibromyalgia

The use of cannabis in fibromyalgia treatment is still an area of ongoing study. CBD and THC have been studied for their potential therapeutic benefits in a variety of medical conditions with manifestations of pain and sleep disturbances. These cannabinoids interact with the body’s endocannabinoid system, which plays a role in regulating pain, mood, and other physiological processes, suggesting that they could play a role in managing the cardinal symptoms of fibromyalgia.

There remains a growing interest in the use of cannabinoids as potential treatment options for fibromyalgia. While some studies show promising results, others have been inconclusive. Overall, the effectiveness of these cannabinoids in treating fibromyalgia remains uncertain. Our investigation revealed that they may be effective in reducing pain and improving sleep in fibromyalgia patients, but more studies are needed to strengthen these findings.

The use of cannabinoids for medical purposes is still relatively new, and much is still unknown. To understand the potential benefits, risks, and optimal dosages and formulations, there is more work to be done through clinical trials. Overall, there remains a potential role for cannabinoids in the management of fibromyalgia, despite currently limited evidence. Nonetheless, more research on this topic is needed to confirm the efficacy of cannabinoids, ascertain the most effective THC–CBD formulation, determine a more standardized assessment for clinical outcomes, and analyze long-term outcomes.

Publisher of open access journals (no date) MDPI. Available at: https://www.mdpi.com/ (Accessed: 23 July 2023).

Parkinsons Disease

CBD as a treatment for Parkinson’s

CBD hasn’t been used in people with Parkinson’s disease long-term, and research into the benefits of this cannabinoid only began a few decades ago.

That means research is limited, and often, the studies that have been done are very small. Scientists and doctors need to conduct larger-scale efforts to confirm any benefits.

However, some studies suggest CBD may have some positive effects, especially when it comes to nonmotor symptoms, such as depression, anxiety, and sleep disorders.

Pain

A small study

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 of 22 individuals with Parkinson’s found that using cannabis helped improve pain. However, this study was conducted with medical marijuana, which contains both CBD and THC.

But animal studies

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 have suggested CBD alone has benefits for reducing pain and inflammation, two factors that can affect people with PD regularly.

Tremors

Some of the most common treatments for Parkinson’s disease can cause medicine-related tremors or uncontrolled muscle movements. Treatment with the medicine won’t make it better — and it could make it worse.

As a possible solution, an older, smaller study

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 has suggested that CBD may be able to help ease these muscle movements.

Psychosis

Psychosis is a possible complication of Parkinson’s disease. It can cause hallucinations, delirium, and delusions, and it’s more common in people in the later stages of the disease.

In fact, up to 50 percent

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 of people with PD experience this complication.

While medications are available to treat Parkinson’s psychosis, some people have wondered if CBD might be beneficial.

One small 2009 study

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 in individuals with Parkinson’s disease and psychotic symptoms found that the compound did reduce the severity of symptoms. It also didn’t cause any adverse effects.

Sleep

Sleep disruption and a lack of quality sleep is a serious concern for people with Parkinson’s disease. Vivid dreams or nightmares, as well as movement during sleep, is common.

Studies

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 have found that both cannabis and CBD alone might help

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 with sleep disturbances.

Quality of life

Because of the many potential benefits of CBD for people with Parkinson’s, researchers have suggested using the compound might help improve quality of life. This is a major concern for individuals living with Parkinson’s disease.

One study

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 found that people who had Parkinson’s disease and no psychiatric symptoms or conditions experienced an improved quality of life with CBD use. This study, too, was done in a very small group of people, so further research is needed to thoroughly support the findings.

Status with the FDA

There are no FDA-approved cannabis treatments for Parkinson’s disease. However, the FDA did approve a CBD medication, Epidiolex, to treat two rare types of epilepsy.

Researchers from the University of Colorado are using that drug to investigate its benefits on people with Parkinson’s-related tremor. The study is in its second phase.

However, this too is a small study, conducted in just 10 people. Larger studies will be needed to confirm or refute what this study ultimately finds.

CBD as a prevention for Parkinson’s

Researchers have found that CBD may be able to help prevent Parkinson’s disease, but currently, research has only been done in animals.

Plus, the research

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 suggests CBD can do nothing to help treat PD once it begins. Based on this, it may only be useful as a preventive measure.

But human studies that analyzed whether CBD could help prevent Parkinson’s didn’t return significant results. More research is needed to understand why the compound might protect animals’ brains but — so far as we can tell — not human brains.

One thing to keep in mind is that by the time an individual begins showing signs of Parkinson’s disease, about 60 percent

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 of the dopamine-receptive neurons in the brain are already destroyed. Most clinical trials only use CBD after a diagnosis is made.

It’s difficult to know who will develop Parkinson’s and who will not. Preventive strategies are few and far between, so knowing who could benefit from CBD prevention measures is difficult.

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Ways to use CBD for Parkinson’s

If you’re a beginner with CBD, you may be curious about the best way to take it if you have Parkinson’s disease.

CBD is available in the following forms:

• Oils and tinctures. As liquids, these forms of CBD can be swallowed or absorbed sublingually (under the tongue). This might be a good option if you have difficulty swallowing pills or chewing gummies.

• Lotions and creams. The effects of CBD-infused lotions and creams can take several hours to develop, but may be useful to treat pain or stiffness in hands and joints.

• Capsules and pills. You may experience a delay in effects if you take CBD in a capsule or pill, but this form may be ideal for people with tremors that prevent them from properly dosing a liquid.

• Edibles. Gummies are a popular CBD option. You can also find CBD in a number of other edible foods, though dosage may not be as accurate as in other forms. Edibles discretely deliver a dose of CBD.

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CBD side effects and risks

In most studies, CBD is tolerated well. It rarely causes side effects, and the ones that do happen tend to be mild. They include tiredness, changes in appetite, and diarrhea or nausea.

However, CBD can interact with prescription and over-the-counter medications. Talk to your doctor before taking CBD, especially if you’re on medications that contain a “grapefruit warning.” CBD and grapefruit have a similar effect on certain enzymes related to drug metabolism.

Holland, K. (2019) CBD Oil for parkinson’s disease: Possible treatment and prevention, Healthline. Available at: https://www.healthline.com/health/parkinsons-disease/cbd-oil-for-parkinsons#side-effects (Accessed: 31 July 2023).